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Background The possibility that vaccination with Adenoviral vectors increased mucosal T-cell activation remains a central hypothesis to explain the potential enhancement of HIV acquisition within the STEP trial. Modeling this within rhesus macaques is complicated because human Adenoviruses, including Adenovirus type 5 (HAd5), do not productively infect macaques. We created a vector based upon a naturally occurring rhesus macaque Adenovirus (SAdV7) to test whether vaccination with as pecies-specific Adenoviral vector enhances mucosal T-cell activation within the natural host.

Increased mucosal CD4+ T-cell activation following vaccination with an adenoviral vector in rhesus macaques