English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background Previous studies of the comprehensive analysis of HIV-1specific CTL responses in Caucasian and African cohorts demonstrated the association of the CTL responses to HIV-1 Gag protein with the control of HIV-1 replication. However, such analysis in Asian cohorts has not been reported. In the present study, we performed the comprehensive analysis of CD8 + T cell responses against 11-mer overlapping HIV-1 Nef, Gag, and Pol peptides in 401 chronically HIV-1 clade B-infected treatment-naive Japanese individuals. Methods The CD8 + T cell responses to cocktails of the peptides were evaluated by measuring IFN-g-producing CD8 + T cells by using ELISPOT assay. Results To clarify CTLs which control HIV-1 infection in this cohort, we statistically analyzed differences of viral load and CD4 counts between responders to each peptide cocktail in each HLA + individuals and non-responders using two-tailed Mann-Whitney’s test. We found that several HLA alleles were significantly correlated with low viral load and high CD4 counts in the responses to 5 Nef, 10 Gag, or 16 Pol cocktails. In these cocktails, we identified 2 Nef, 12 Gag and 7 Pol CTL epitopes restricted by 9 HLA alleles. The breadth of CTL responses to these epitopes was significantly associated with low viral load (p=1.7x10 -10 ) and high CD4 counts (p=4.1x10 -13 ). The total magnitude of responses to the epitopes was also

Control of HIV-1 by multiple immunodominant HIV-1-specific CD8+ T cells in HIV-1-infected Japanese individuals