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Background Designed Ankyrin Repeat proteins (DARPins) are a novel type of binding protein scaffold designed as antibody alternative for biomedical applications. DARPins share many properties with antibodies, most noteworthy a high target specificity and affinity, but they differ from antibodies in size, structure and binding pattern and, importantly, favorable biophysical properties such as exceptional stability. This together with high-yield prokaryotic production renders DARPins promising candidates for microbicide development.

Conformation-dependent recognition of HIV Gp120 by DARPins provides novel possibilities to develop distinct HIV entry inhibitors