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Methods Seventy-two HIV-uninfected partners (50% women) in Uganda were randomized to daily or intermittent (Monday, Friday and within 2 hours after sex, not exceeding 1 dose/day) oral emtricitabine/tenofovir or placebo in a 2:1:2:1 ratio for four months. Adherence was assessed monthly by MEMS and self-reported taken or missed doses by timeline follow-back calendar. MEMS data was adjusted for extra openings without pill removal and removal of multiple pills. Non-fixed days within intermittent regimen were classified as adherent/non-adherent based on self-reported sex by SMS. Adherence rates by taken/missed doses were compared to raw MEMS data using Spearman correlation.

Performance of self-reported adherence to oral pre-exposure prophylaxis (PrEP) among HIV heterosexual serodiscordant couples in rural Uganda