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Background HIV-1 transmission occurs predominantly through mucosal surfaces. In macaque models of SHIV mucosal transmission, passive administration of the monoclonal neutralizing antibody IgG1 b12 (b12) can protect against virus infection. However, an Fc variant of b12, deficient in FcgR and complement binding, (LALA) had diminished protective capacity. Concentrations and kinetics of b12 and LALA in serum and in mucosal secretions were determined in the protection studies, but the biodistribution and kinetics of the antibodies in mucosal and lymphatic tissues and around the site of viral challenge have not been assessed.

Biodistribution of neutralizing monoclonal antibodies IgG1 b12 and LALA in mucosal and lymphatic tissues of rhesus macaques