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Results The thickness of the ectocervical epithelium was significantly higher in HESN vs. lower risk subjects. CD4 and DC-SIGN mRNA expression was significantly lower in HESN than lower risk women, and in situ immunohistochemical analysis confirmed the reduced CD4 expression in HESN participants. In addition, immunohistochemistry demonstrated lower CCR5 and higher Langerin expression in the HESN subjects.

Increased epithelial thickness and reduced HIV receptor expression in the ectocervical mucosa is associated with relative HIV resistance