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Background We previously reported that HIV Exposed Seronegative (HESN) individuals have a higher frequency than HIV infected subjects of 2 genotypes: homozygosity for Killer Immunoglobulin-like Receptor (KIR) 3DS1 (KIR3DS1hmz) and homozygosity for high expression KIR3DL1 genotypes co-expressed with HLA-B*57 (*h/*y +B*57). KIR3DL1/S1 are Natural Killer (NK) cell receptors that influence NK functionality. Here, we assessed whether these genotypes were associated with protection by parenteral and mucosal routes of HIV exposure.

Are the KIR3DS1homozygous and KIR3DL1*h/*y+HLA-B*57 genotypes associated protection from HIV by different routes of exposure?

Are the KIR3DS1homozygous and KIR3DL1h/y+HLA-B*57 genotypes associated protection from HIV by different routes of exposure?