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Background Recently HIV infected individuals are followed up at Rwanda-Zambia HIV Research Group (RZHRG) sites to establish markers of disease progression. Here we compare disease progression between seroconverters infected by their spouses (linked transmission) to those infected by non-spousal partners (unlinked transmission) where a greater fraction of individuals are infected by multiple virus variants. Methods Seroconverters (SC) were identified from HIV discordant couples enrolled from the Couples’ VCT program into a prospective cohort study. Linkage of transmission was established by comparing viral DNA sequences in the SC to that of the suspected index partner. SCs were followed up to six years to collect clinical and laboratory data. Data analysis using STATA was done on CD4 and viral load trajectories and a comparison of disease progression with respect to time to endpoints of CD4 <350 cells/uL and initiation of ARVs. Log rank test of equality for survival function was performed for each endpoint and p-values calculated.

HIV disease progression compared by linkage status in Rwanda and Zambia