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Background The immune response of HIV-infected individuals shapes the evolution of the virus by selecting escape mutation. After transmission to a new host, the HLA-mediated immune pressure changes. The objective of our study was to characterize the dynamics of HLA-anchor escape mutations after transmission. Methods We studied 6 transmission events between members of serodiscordant couples collecting blood samples from the donor and the previously seronegative-partner at the moment of seroconversion, and a second sample at least 6 months post-infection. HLA-I typing was performed by the SSOP-PCR method. The viral gene gag was amplified by RT-PCR and cloned into the pGEM-T vector for viral quasiespecies analysis. Transmitted strain was identified by phylogenetic analysis. Escape mutation was defined as viral polimorphisms located in HLA-anchor position that eliminate an epitope predicted by the NetMHC (CBS Prediction Server). Significant variations in the number

Low selection rate of HLA-anchor escape mutations in HIV after transmission of subtype B and recombinants BF strains patients from Argentina