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Background HVTN 078 is a phase 1b clinical trial of heterologous vector prime/boost vaccine regimens (NYVAC-B/rAd5 vs. rAd5/NYVAC-B) in healthy, HIV-1 uninfected, Ad5 seronegative adults. The rAd5 expressed a clade B GagPol fusion protein and secreted gp140s of HIV-1 strains 92RW020 (clade A), HxB2/Bal-V3/ V1V2 (clade B) and 97ZA012 (clade C). The NYVAC-B expressed a clade B Gag-Pol-Nef polyprotein and the secreted gp120 of Bx08 (clade B). A total of 80 participants were randomized into a placebo group (P) and four treatment groups: T1, 2x NYVAC-B/1x rAd5 (10); T2, 1x rAd5 (10)/2x NYVAC-B; T3, 1x rAd5 (10)/2x NYVAC-B; T4, 1x rAd5 (10)/2x NYVAC-B.

rAd5/NYVAC-B is superior to NYVAC-B/rAd5 and is dependent on rAd5 dose for neutralizing antibody responses against HIV-1