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Methods In this study, 12 RM were infected with SIVmac239 (i.v., 300 TCID50). rMamu IL 21-Fc fusion protein (50mg/kg) was given s.c on a weekly basis post infection (pi) for 5 doses on days14, 21, 28, 35 and 42pi to 6 animals, designated as “treated”, with 3 mamuA01+ animals each in treated and control groups. Samples of PBMC, bone marrow (BM), rectal biopsy (RB) and peripheral LN (LN) were collected before infection (d-11), and at various times post infection.

Recombinant IL-21 induces perforin and granzyme B in total and virus specific CD8 Tcells in acute and early stages of SIV infection in rhesus macaques