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Background Recruitment of lowand middle-income country volunteers from most-at-risk-populations in HIV vaccine trials is essential to vaccine development. In India, men who have sex with men (MSM), at 20-fold higher risk for HIV infection than the general population, are a crucial population for recruitment. Research on willingness to participate (WTP) in HIV vaccine trials has focused predominantly on individual-level determinants (e.g., safety concerns, mistrust, altruism) in high-income countries. We used a social ecological framework to explore multi-level determinants of WTP among MSM in India.

A social ecological model of willingness to participate in HIV vaccine trials among men who have sex with men in Chennai and Mumbai, India