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Background Previous studies examining barriers and willingness to participate in HIV vaccine trials have demonstrated the role of factors identified by the Health Belief Model. Barriers to cancer trials can also be understood in terms of a theoretical framework consisting of the locus of the barrier (personal vs. social) and the nature of the barrier (risk vs. cost). In this systematic review of review articles, we extend this framework to another life-threatening disease, cancer. The purpose is to improve conceptual clarity about volunteering in clinical trials by comparing and contrasting barriers in these two areas. Methods

Barriers to participation in HIV vaccine trials and cancer trials: a cost-gain analysis