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Background The membrane proximal external region (MPER) of the HIV surface glycoprotein gp41 is the binding site for several potent broadly neutralizing antibodies. These antibodies recognize highly conserved linear peptide epitopes and antigens derived from this region have the potential to be important components of a vaccine directed against HIV-1. Highly conserved peptide epitopes for these antibodies are sterically obscured from the immune system by an intimate association with the viral membrane and by the presence of a large trimeric glycoprotein spike. As a result, previous attempts to immunize with linear peptides have failed to elicit broadly neutralizing antibodies.

Analysis of gp41 epitopes in model viral membranes to study HIV-1 neutralization