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Background Despite progress in identifying targets of neutralizing antibodies and T cell immunity, many HIV antigens have been weak immunogens. We have developed rubella as a live viral vector to enhance immunogenicity by presenting HIV and SIV antigens in the context of an acute infection. These vectors are based on the rubella vaccine strain RA27/3: safety and immunogenicity have been established in millions of children around the world. If the vector loses its insert, it would revert to the vaccine strain. It is immunogenic: one dose protects for life (against rubella). It elicits mucosal and systemic immunity. Rubella readily infects rhesus macaques, and these animals can test vector growth, immunogenicity and protection against SIV or SHIV challenge.

Live, attenuated rubella vectors expressing HIV and SIV vaccine antigens