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Background Humoral immune responses elicited by an HIV vaccine would ideally be comprised of durable high titers of broadly neutralizing antibodies. Importantly, recent studies of broadly neutralizing antibodies isolated from infected patients have suggested that high degrees of somatic hypermutation (SHM) are a common feature of antibodies with high potency and good breadth. Thus, a successful vaccine will likely require both immunogens capable of focusing the humoral response against conserved neutralizing epitopes and appropriate adjuvants/delivery systems capable of promoting elevated SHM and lasting responses against these epitopes.

Shaping humoral responses against mini-libraries of HIV env antigens via lipid nanoparticle vaccine delivery