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Methods A Phase 1 trial was conducted in two parts. In Part A, (open-label) 19 volunteers received oligomeric gp160 MN/LAI-2 (ogp160) with a dose escalation (25, 50, 100 μg). In Part B, 72 volunteers (60 active, 12 placebo) received placebo or recombinant canarypox expressing HIV-1 antigens, (ALVAC-HIV, vCP205) prime with different doses and schedules of ogp160MN/LAI-2 in alum or polyphosphazene (PCPP).

Safety and immunogenicity of a randomized phase I prime-boost trial with ALVAC-HIV (vCP205) and gp160 MN/LAI-2 adjuvanted in alum or polyphosphazene