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Background Fc-mediated inhibitory activity of neutralizing antibodies has been shown to participate in HIV protection (Hessell et al. 2007). In addition, a non-neutralizing antibody F240 was found to partially protect macaques from SHIV vaginal transmission (Moore et al., 2011). However, mechanisms involved in this protection need further investigations. In this study, two non-neutralizing antibodies have been selected on the basis of their Fc-mediated inhibitory functions in vitro for further analysis of their protective role on vaginal challenge in non-human primate (NHP).

Non-neutralizing IgG anti-PID antibodies decreased viral load following high dose vaginal challenge of non-human primates