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Background The induction of a potent humoral and cellular immune response both in the peripheral and mucosal tissues is important for the development of an effective HIV vaccine. The present study explores the ability of a Lactococcus lactis (L. lactis), a probiotic organism, based oral vaccine to elicit HIV-specific immune responses in the mucosal and systemic compartments of mice and rhesus monkeys.

Oral immunization with a recombinant Lactococcus lactis expressing HIV-1 Gag on the tip of the pilus induces strong mucosal immune responses