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Background Generation of infectious HIV-1 requires the synthesis of the spliced and the Rev responsive element (RRE)-containing viral transcripts. The former is efficiently processed and rapidly exported to the cytoplasm. The latter retains introns in unspliced and partially spliced forms and does not exit the nucleus until the viral Rev protein mediates its export for the expression of structural proteins and for the production of full-length genomic RNAs. Rev by binding to RRE increases the halflife of unspliced/ partially spliced RNAs and promotes their export to the cytoplasm. Various cellular factors have been reported to contribute to Rev activities but the molecular details of how Rev overcomes the eukaryotic restriction for intron-containing mRNAs remain to be determined.

Characterization of the HIV-1 RNA associated proteome identifies Matrin3 and PSF as nuclear cofactors of Rev function