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Background Binding of the gp120/gp41 complex to CD4/coreceptors is cooperative, requiring three CD4 binding events, four to six coreceptors, and multiple clusters of gp120/gp41 to effectively form a fusion pore.[1] An engineered CD4 mimetic mini protein (miniCD4) [2] and the third variable region (V3) of gp120 [3] are peptides able to block HIV entry. Gold nanoparticles covered with carbohydrates, peptides or proteins are useful tools to study biological processes where multivalence is crucial. [4] In this work we present the study of the multimerization of miniCD4and V3 peptides onto gold glyconanoparticles (GNPs).

Glyconanoparticles as a platform to multimerize peptides involved in HIV entry process