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Background We have previously found that the novel tetramethylnaphthalene derivative TMNAA selectively inhibits the proliferation of HTLV-1-infected T-cell lines but not HTLV-1-uninfected T-cell lines. Although its target molecule is still unknown, TMNAA did not affect NFB activity. Therefore, we further examined the antiproliferative activity of TMNAA against various T-cell lines in combination with cepharanthine (CEP), which is known to inhibit NFB.

A novel tetramethylnaphthalene derivative synergistically inhibits HTLV-1-infected cell proliferation in combination with cepharanthine