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Background It’s estimated that 10 to 20 million people are infected with the HTLV-1 virus worldwide. Two principal diseases are associated with this virus: the Adult T-cell Lymphoma/Leukemia (ATLL), and the HTLV-1 Associated Myelopathy/ Tropical Spastic Paraparesis (HAM/ TSP). The last one is a debilitating neurological disease characterized by a chronic progressive paraparesis, with autonomic and mild sensorial complains. There are also incomplete forms of HAM/TSP, sometimes called subclinical or oligosymptomatic. Those mild and moderate neurological presentations are found in almost one fourth of the HTLV-1 patients and they include neurogenic bladder syndromes, erectile dysfunction, isolated pyramidal signs and peripheral neuropathy.

Neurological disability in HTLV-1 infected individuals according to the initial clinical presentation: cohort study