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Background HTLV1 may exert an initial pro-apoptotic stimulus via Tax-induced DNA damage. On the other hand, Hbz protein antagonizes some Tax effects on gene expression and hbz mRNA has been proposed as essential for maintaining oncogenesis. We hypothesize that expression of the hbz gene contributes to overcoming the pro-apoptotic signals in HTLV1 infected T-cells with DNA damage. To test this hypothesis we studied the expansion of infected cells with high DNA damage and investigated whether hbz mRNA supports survival of those cells.

Expression of hbz mRNA promotes survival in HTLV-1-infected cells with high DNA damage