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Background Associated treatment with pegylated interferon plus specific antiviral compounds significantly improved the prognosis of chronic hepatitis C and hepatitis B even when an underlying HIV infection is of concern, although antiviral drugs (especially interferon and its derivatives), tend to be myelotoxic and also some rescue treatments, like human recombinant granulocyte colony-stimulating factors (G-CSF, filgrastim or lenograstim) (which are extensively administered in order to correct neutropenia induced by antiviral therapy), may also be involved in prompting or exacerbating cutaneous psoriasis and its systemic complications.

retrovirology

Severe psoriasis emerged after treatment of chronic HCV co-infection with pegylated-interferon and ribavirin, supported by neutropenia rescue with repeated filgrastim administration