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Background “Highly active antiretroviral therapy” (HAART) has dramatically increased the life expectancies of HIV positive humans. Due to this progress, other HIV-infection associated consequences like the HIV-associated neurological disorders (HIV-ND) are becoming more and more significant. The HIV Nef protein seems to play an important role in progression of HIV-NDs. We set out to identify brain tissue specific ligands of membrane associated Nef.

Potential role of HIV-1 Nef and human M6B in HIV-associated neurological disorders