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Methods The three teams are using diverse but complementary capacity building approaches with a mix of African-Canadian and African-African research partnerships. In West Africa, a Benin-Canada partnership is strengthening capacity for clinical trials by: 1) training African investigators; 2) supporting the creation of the national Ethics Committee for health research in Benin; and 3) supporting the creation of a HIV/STI Prevention Research Unit within the Faculty of Health Sciences in Benin. A second Africa-Canada team created and supported the CanadaAfrica Prevention Trials (CAPT) network which facilitates north-south and south-south research partnerships in this domain. The third team used the grant to build the African Development of AIDS Prevention Trial (ADAPT) capacity program. This program is strengthening the capacities of local health systems to design, conduct, and use the evidence from large-scale AIDS prevention trials in southern Africa. Results These three projects are helping to build African capacity to undertake HIV/AIDS clinical trials in Africa by: 1) combining capacity building strategies both at the individual institutional levels and 2) strengthening a range of skills and knowledge that includes epidemiology, community and stakeholder engagement, research management, research ethics and grant writing.

P06-05. Building capacity for HIV/AIDS prevention trials in Africa: Evidence from three projects supported by the Global Health Research Initiative