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Background While neutralizing antibodies should limit the replication of HIV/SIV in the infected individual, autologous neutralizing antibodies are generated too late following HIV/SIV infection to contribute to early virus control. The present study addresses whether vaccine-induced immune responses accelerate the generation of autologous neutralizing antibodies following SIV challenge in rhesus monkeys, and if this antibody response shapes viral sequence evolution.

P04-41. Kinetics of antibody neutralization and viral evolution following envelope vaccination in SIV-infected rhesus monkeys