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Background Natural killer (NK) cells play an important role in antiviral immune responses; they kill HIV-1-infected cells either by direct lysis or through an antibody-dependent cellular cytotoxicity (ADCC) mechanism. HIV-1-specific ADCC were mainly detected using the CEM-NK target cell line. The aim of our study was to analyze the ADCC activity of various HIV-1-specific antibodies with an assay involving primary activated NK cells and autologous infected CD4 T-lymphocytes.

P04-36. HIV-1-speficic antibody dependant cellular cytotoxicity (ADCC) médiated by primary NK cells