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Background The majority of HIV particles produced in vivo are noninfectious due to incorrectly processed or incomplete envelope spikes, and may act as potential decoys for humoral immunity. Specific targeting of the infectious subpopulations of virions by vaccine-induced antibodies may be required for sterilizing immunity. We have assessed the impact of defective Env, associated with noninfectious virions on the activity of neutralizing/non-neutralizing mAbs targeting different components of the Env.

P04-30. Sorting of infectious and non-infectious viral particles by Env-specific mAb