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Background Developing a safe and effective HIV-1 vaccine has been hampered by the inability to design immunogens that can induce antibodies capable of potently neutralizing diverse HIV-1 strains. Despite the recognition of conserved HIV-1 envelope (Env) regions by rare, broadly neutralizing antibodies, these regions fail to induce protective antibodies when used as immunogens or in the context of natural infections. Various hypotheses have been offered to explain the absence of an effective immune response to Env determinants, including the suppression of this response by immunological tolerance. This hypothesis arose from the observation that broadly neutralizing HIV1 antibodies can cross-react with self-antigens.

P04-26. Immunological tolerance prevents the expression of a broadly reactive neutralizing HIV-1 antibody