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Background Study and direct comparison of HIV-1 Env specific antibody responses elicited by HIV vaccines can provide useful information to identify vaccine candidates in early stage trials with greater potential of providing a protective immune response. With the goal of describing qualitative differences in humoral responses elicited by disparate HIV vaccine delivery approaches, we evaluated serum samples from three independent trials: HVTN 041, a recombinant protein based vaccine; HVTN 203, a combination canarypox prime plus protein boost vaccine, and DP6-001, a DNA prime plus protein boost vaccine.

P04-21. Different human serum antibody profiles elicited by three candidate HIV vaccines using different immunization approaches