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Background The most useful model system for HIV vaccines is SIV infection of non-human primates (typically rhesus macaques). The pathogenic SIV strains in common use were derived from macaques infected in captivity by viruses originally from sooty mangabeys. In the course of developing new viral stocks and vaccine antigens for challenge studies, we investigated the mode of evolution in natural SIV isolates from sooty mangabeys, comparing it to that of HIV-1 isolates from the global pandemic.

retrovirology

P20-21 LB. Gene-to-gene differences in evolutionary rate between HIV-1 and natural SIV from sooty mangabeys: implications for vaccine tests in non-human primates