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Background Antibodies induced by a vaccine that will protect against infection by HIV-1 will be heterologous, yet, little is known on how virus evolution affects neutralization sensitivity to heterologous antibodies. Therefore, experiments were performed to test the sensitivity of sequential HIV-1 primary isolates to anti-HIV-1 monoclonal antibodies (mAbs) and to analyze changes in the neutralization epitopes.

P04-14. Sequential HIV-1 isolates from infected individuals reveals emergence of neutralization sensitive HIV-1 strains in the course of infection