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Methods In this study, we developed a recombinant replicationcompetent modified vaccinia Tiantan (MVTT), namely rMVTTSIVgpe, as a mucosal vaccine expressing SIVmac Gag, Pol and Env. The immunogenicity and efficacy of rMVTTSIVgpe was studied in combination with an rAd5based vaccine rAd5SIVgpe in Chinese macaques (Macaca mulatta) without the protective MHC class I allele MamuA*01. rMVTTSIVgpe was given through intranasal and oral inoculations whereas rAd5SIVgpe was given through intramuscular injection. Four macaques in each of the four study groups received the following prime and boost vaccinations: rMVTTSIVgpe/rAd5SIVgpe; rMVTTSIVgpe/rAd5SIVgpe, twice; rAd5SIVgpe/rAd5SIVgpe; and placebo controls, respectively.

P19-55 LB. Effective control of a pathogenic SIVmac239 challenge by a novel heterologous mucosal prime and intramuscular boost vaccine strategy