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Results The results indicate that the possession of the MPER 4E10 epitope by pseudoviruses is sufficient for neutralisation by the 4E10 MAb. However, the addition of the 4E10 epitope reduced expression of gp140 from stable CHO lines by over 50% and has a marked effect on the binding of the b12 MAb, which recognises the CD4 binding site, and sCD4. Finally, mean end-point antibody titres from immunised rabbits were lower in animals immunised with C-clade gp140 which contains the 4E10 epitope. An analysis of breadth and potency of neutralising responses raised in these animals is underway. Conclusion The data suggests that the addition of the 4E10 epitope to HIV-1 gp140 has profound effects on the structure of gp140, which affects the expression levels, antigenicity and immunogenicity of these glycoproteins. from AIDS Vaccine 2009 Paris, France. 19-22 October 2009

P19-54 LB. Interrogating the membrane-proximal external region (MPER) of HIV-1 gp140