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Background The variability of HIV and the appearance of escape mutants are a major obstacle for HIV/AIDS vaccine development. In previous phase I/II studies recombinant MVANef and MVA-BN®-Polytope expressing conserved epitopes from multiple proteins of HIV-1 induced good and broad cellular immune responses and indicated an inhibitory effect on viral replication during treatment interruption (MVA-Nef). To further broaden the immune responses a new MVA-BN®-Multiantigen vaccine candidate expressing full length or truncated HIV-1 proteins (gag, pol, nef, tat, vpr, vpu, vif, rev) has been developed and tested for safety and immunogenicity.

retrovirology

P18-12 LB. Phase I clinical trial with a new recombinant MVA-BN®-multiantigen vaccine: high responder rate and considerable breadth of immunological response