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Background A previous therapeutic vaccine pilot study based on autologous dendritic cells pulsed with autologous heat inactivated viruses HIV-1 obtained by plasmapheresis, showed a decrease in the plasma viral load in 4 of 12 chronically HIV-1-infected patients [Garcia et al., J Infect Dis. 2005; 191: 1680–1685]. This vaccination strategy required to submit the infected patients to 2 structured treatment interruptions (STI): the first to recover enough viruses to be used as antigen, and the second to assess virological responses after the immunization. We aimed to study the viral variability evolution changes occurring during off therapy period, before and after vaccination.

retrovirology

P20-06. Study of viral variability evolution in patients submitted to a therapeutic vaccine based on autologous dendritic cells pulsed with autologous HIV-1