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Background Experiments were designed based on the hypothesis that recombinant vaccine constructs can focus the immune response on shared HIV-1 neutralizing epitopes, and that if not diverted by other biologically irrelevant epitopes, high titers of cross-clade neutralizing antibodies (ccNAbs) will be induced. Indeed, previous experiments showed that when the immune response was focused on V3, ccNAbs were induced (Zolla-Pazner et al, Virology, 2008).

P04-09. Induction of cross-clade neutralizing antibodies with a prime/boost vaccine strategy focused on a neutralizing epitope