English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background Co-stimulatory molecules play a critical role in the development of cellular immunity. Understanding how costimulatory pathways interact and influence the immune response is critical for the generation of an effective HIV vaccine. We evaluated the ability of intravenous administration of blocking monoclonal antibodies (mAb) directed against the negative co-stimulatory molecule, CTLA-4, and an agonist mAb directed against the positive co-stimulatory molecule, 41BB, to augment intramuscular SIV DNA immunizations. We then tested the ability of these responses to impact a SIVmac251 challenge.

P19-49. Modulation of vaccine induced responses through CTLA-4 and 41BB enhances protection in macaques following SIVmac251 challenge