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Background Since none of the developed candidate vaccines against HIV has been effective, novel vaccine concepts are needed. Our group has identified conserved HIV CD4+ T cell epitopes binding promiscuously to multiple HLA-DR molecules, and frequently recognized by HIV-1-infected patients. A DNA vaccine encoding such epitopes (pVAXHIVBr18) showed strong cellular responses in mice. An early CD8+ T cell response against Vif is associated with control of SIV infection in primates. A vaccine capable of stimulating both CD4+ and CD8+ T cells can be useful to establish an appropriate immune control of HIV. We aim to test whether preimmunization with pVAX-HIVBr18, which contains the CD4/CD8 Vif (144-158) epitope, can boost Vif-specific CD8+ T cell responses after immunization with a plasmid encoding Vif (pVAX-Vif).

P19-44. Priming with a DNA vaccine enconding HIV CD4+ T cell epitopes enhances responses against subsequent immunization with plasmid encoding Vif