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Background Immunization against chronic life threatening viral infections such as HIV remains an elusive goal. Data from clinical and non-human primate studies suggest that the generation of potent CD8 T cell responses as well as broadly neutralizing antibodies will be needed for protective immunity against AIDS. Because of its well known ability to stimulate such immune responses, we have explored the potential of a replication-defective recombinant lymphocytic choriomeningitis virus (rLCMV) vector to elicit antigen-specific immunity to HIV-1.

P19-37. Replication-defective lymphocytic choriomeningitis virus vectors boost cellular and humoral immunity after DNA or adenovirus vector priming