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Background The general objective has been to generate the genetic vaccine vector that assures induction of strong and protective T-cell and B-cell immune responses against the HIV1. We have developed Gene Transport Unit (GTU®) plasmid vector system, which uses bovine papillomavirus type 1 segregation/partitioning and transcription activation functions provided by the viral E2 protein and E2 multimeric binding sites. The GTU® vectors assure high level, targeted and extended expression of the viral antigens for the genetic vaccines.

P19-30. GTU® as beneficial HIV DNA vaccine vector system