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Background The human immunodeficiency virus envelope spike is the key mediator of membrane fusion with the host cell and is a promising research target for vaccine development. The surface spike gp120 and the transmembrane protein gp41 result from cleavage of immature cytosolic gp160 and are expressed as trimers. Conformational rearrangement upon binding of gp120 to host CD4 receptors and chemokine coreceptors mediates membrane fusion, exposes the fusion peptide of gp41 and enables viral genome insertion.

P19-23. Putative prefusion mechanism of HIV-1 Env revealed by ligand-induced quaternary alterations in o-gp140 trimers