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Background Utilizing plants to produce pharmaceutical products, including antigens for AIDS, is a new way to produce vaccines. HIV-1 Tat plays a major role in viral replication and is essential for AIDS disease development making it an ideal vaccine target provided that both humoral and cellular immune responses are induced. Previous attempts to express Tat in tomato only reported successful humoral immune responses induction while certain physiological abnormalities were also observed in tomato which would be detrimental to furthering plant-based HIV vaccine development. In this study, an in-depth understanding of the effects of Tat expression in tomato and its immunogenicity was determined.

P19-16. Potential of an HIV-1 Tat fusion protein expressed in tomato as a plant-based HIV vaccine