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Background There are a number of monoclonal antibodies possessing neutralizing activity against the broad range of HIV-1 isolates. Some of them recognize conformational epitopes of HIV-1 antigens. Obviously, artificial anti-HIV polyepitope vaccines should induce a necessary spectrum of broadly neutralizing antibodies. Polyepitope TBI protein containing 4 T-cellular and 5 B-cellular linear epitopes from Env and Gag proteins of HIV-1 has been created earlier. Three linear peptides imitating natural HIV-1 conformational 2G12-determinant were selected using phage display and inserted in TBI.

P19-13. Recombinant proteins carrying peptide mimics of HIV-1