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Background Human cytomegalovirus (HCMV) is a ubiquitous herpesvirus responsible for asymptomatic, dormant, lifelong infection in healthy individuals. HCMV frequently reactivates inducing a strong, mucosally-oriented immune response. These features of HCMV provide advantages over other viral vectors investigated to date as HIV vaccine candidates. Therefore, we hypothesize that an HCMVbased vaccine can elicit safe and protective HIV-specific immunity in humans. Cytomegaloviruses are highly species-specific viruses and generally restricted in their ability to infect even closely related hosts. Therefore, to test our hypothesis, we propose to use rhesus cytomegalovirus (RhCMV), a non-human primate cytomegalovirus, as a vaccine vector to induce protective immunity to simian immunodeficiency virus (SIV) in cynomolgus macaques (CM). RhCMV is considered the best animal model for HCMV, and SIV pathogenesis in CM closely mimics HIV/ AIDS pathogenesis in humans.

P19-07. Development of a protective HIV/SIV vaccine based on a self-boosting cytomegalovirus vector