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Background Antigen-presenting dendritic cells (DC) present viral antigens to T-cells after uptake of apoptotic bodies derived from virus-infected cells. Besides, processing and presentation of ingested antigen, DC were recently shown to be able to incorporate part of the DNA from the apoptotic cells into their own chromosomes and express the encoded antigens. This mechanism could lead to a more efficient presentation of foreign antigens and activation of antigen specific naive T-cells. It was recently exploited for induction of HIV specific immune responses in a HIV-1/ MuLV mouse infection model.

P19-05. Use of autologous apoptotic pseudovirus infected cells for vaccination against HIV, evaluation in macaques