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Methods Full-length gag sequences of 1.5 kb derived from 156 CRF01_AE and 72 Asian HIV-1 subtype B were computerized to generate 3 representative mosaic Asian HIV-1 gag genes. The mosaic gag genes were RNA-optimized and cloned into pCMVkan expression vector. Mice were immunized by intradermal (ID) and needle-free injector (NF) using 100 and 50 μg, respectively, of the 3 mosaicgag mixtures. The vaccinations were performed on days 0, 14 and 28. An additional group received 5-million pfu vaccinia-AE boost on day 42. Mice were sacrificed on day 35 (DNA alone) and day 49 (DNA prime/vaccinia boost) and the immunogenicity was assessed by anti-p24 antibody and IFN-gamma ELISpot assays. Both HIV-1 AEand B-peptide pools were used separately to stimulate splenocytes.

P19-01. Pre-clinical immunogenicity of mosaic Asian AE/B HIV-1 DNA vaccine in mice