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frequency of IFN-gamma ELISpot response to Clade B Gag (P < 0.005), Pol (P < 0.05), and Clade A (P < 0.005), B (P < 0.005), and C Env (P < 0.05) overlapping 15 mer peptides. This increase was in part due to an increase in number of epitopes recognized. IFN-gamma ELISpot responses to Clade B Nef, not targeted by Ad5 boost vaccination, were not significantly increased in vaccinees. No significant change was observed in controls.

P18-06. Increased HIV-specific immunity in HIV-infected individuals vaccinated with a DNA prime, rAd5 boost regimen